Bookedited by Hisao Masai, Marco Foiani.
Summary: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells? strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Contents:
Preface
Biography
Chapter1. Historical Perspective of Eukaryotic DNA Replication
Chapter2. Regulation of replication origins
Chapter3. Molecular mechanism for chromatin regulation during MCM loading in mammalian cells
Chapter4. Initiation of DNA replication at the chromosomal origin of E. coli, oriC
Chapter5. Initiation of DNA replication in the archaea
Chapter6. Mechanism of lagging strand DNA replication in eukaryotes
Chapter7. Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication
Chapter8. Termination of eukaryotic replication forks
Chapter9. Structure of the MCM2-7 double hexamer and its implications for the mechanistic functions of the Mcm2-7 complex
Chapter10. Architecture of The Saccharomyces cerevisiae Replisome
Chapter11. Replication domains: genome compartmentalization into functional replication units
Chapter12. Rif1-dependent regulation of genome replication in mammals
Chapter13. G-quadruplexes and DNA replication origins
Chapter14. Interaction of Rif1 protein with G-quadruplex in control of chromosome transactions
Chapter15. Chromatin replication and histone dynamics
Chapter16. The temporal regulation of S phase proteins during G1
Chapter17. Roles of SUMO in replication initiation, progression, and termination
Chapter18. The multiple roles of ubiquitylation in regulating challenged DNA replication
Chapter19. Regulation of mammalian DNA replication via the ubiquitin-proteasome system
Chapter20. Coordinating replication with transcription
Chapter21. Fragility extraordinaire: Unsolved mysteries of chromosome fragile sites
Chapter22. Cyclin E deregulation and genomic instability
Chapter23. Replication through repetitive DNA elements and their role in human diseases.