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  • Book
    [edited by] Charles E. Argoff, Andrew Dubin, Julie Pilitsis.
    Summary: "For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Pain Management Secrets, 4th Edition, features the Secrets' popular question-and-answer format that also includes lists, tables, and an easy-to-read style - making reference and review quick, easy, and enjoyable"--Publisher's description.

    Contents:
    I. Overview. Definitions
    Classification of pain
    Basic mechanisms
    Topiceuticals
    II. Clinical approach. History taking in the patient with pain
    Physical examination of the patient with pain
    Pain measurement
    Psychological assessment of chronic patients
    III. Clinical syndromes defined by pain. Neuroimaging in the patient with pain
    Tension-type headache
    Migraine
    Cluster headache
    The paroxysmal hemicranias
    Subarachnoid hemorrhage
    Brain tumor headaches
    Increased and decreased intracranial pressure
    Temporal giant cell arteritis
    Headaches associated with systemic disease
    Trigeminal neuralgia
    Glossopharyngeal and other facial neuralgias
    Low back pain
    Neck and arm pain
    Abdominal pain
    Chronic pelvic pain
    Fibromyalgia and myofascial pain
    IV. Syndromes in which pain is a significant component. Postoperative pain management
    Cancer pain syndrome
    Pain in rheumatoid arthritis and osteoarthritis
    Neuropathic pain
    V. Psychological syndromes
    VI. Special patient populations. Pain in children
    Pain in the older patient
    VII. Pharmacologic management. Nonsteroidal anti-inflammatory drugs
    Opioid analgesics
    Addiction and pain management
    Regulatory issues
    Adjuvant analgesics
    VIII. Nonpharmologic management. Temporary neural blockade
    Permanent neural blockade and chemical ablation
    Sympathetic neural blockade
    Intraspinal opioids
    Neurostimulatory and neuorablative pocedures
    Psychological constructs and treatment interventions
    Physical modalities: adjunctive treatments to reduce pain and maximize function
    Pain clinics
    Interventional pain management
    Complementary and alternative medicine.
    Digital Access ClinicalKey 2018
  • Article
    Minshew BH, Swanzy SR, Schoenknecht FD.
    Antimicrob Agents Chemother. 1977 Nov;12(5):597-601.
    The radioenzymatic technique using aminoglycoside-6'-acetyltransferase is suitable for determining serum concentrations of aminoglycoside antibiotics that have a 6'-amino group. Standard curves constructed for each drug in normal human serum are generally satisfactory, but we encountered a pool of human serum (designated IN pool) that inhibited the acetylating activity of the assay. Standard curves for amikacin, kanamycin, gentamicin, and tobramycin in the acetylating assay were all abnormal with standards prepared in the IN pool. Acetylating activity was also inhibited with amikacin standards prepared in a filtrate of this serum pool. Heat inactivation (56 degrees C for 30 min) of the IN pool did not eliminate the problem. When the IN pool was diluted 1:10 in normal human serum, the standard curve obtained with amikacin was comparable to the curve with standards prepared in normal human serum. With amikacin standards prepared in a 1:2 dilution of the IN pool in normal human serum, an intermediate level of acetylating activity was observed. When this IN pool was used for the preparation of gentamicin and amikacin standards in a bioassay with Klebsiella pneumoniae ATCC 27799 as the test strain, valid standard curves and concentrations were obtained. Furthermore, no differences in the biological activity of amikacin were observed with Pseudomonas aeruginosa or Bacillus subtilis as the test strain. Excellent agreement between the microbial assay and the enzymatic assay was obtained with serum specimens tested for gentamicin (r = 0.89), tobramycin (r = 0.96), and amikacin (r = 0.96). The results obtained with the IN pool illustrate the need for regular use of check samples of known performance, independent from the standards, when determining antibiotic levels in serum.
    Digital Access Access Options