BookEditors, David Stewart and Bruce Stillman.
Summary: The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genes and Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth & Progression; Innate & Adaptive Immune Responses; and Enabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.
Contents:
Symposium participants
Foreword. Cancer stem cells : Normal and neoplastic stem cells / Melissa N. McCracken, Benson M. George, Kevin S. Kao, Kristopher D. Marjon, Tal Raveh, and Irving L. Weissman
Targeting the epithelial-to-mesenchymal transition: the case for differentiation-based therapy / Diwakar R. Pattabiraman and Robert A. Weinberg
Trimming the vascular tree in tumors: metabolic and immune adaptations / Elizabeth Allen, Rindert Missiaen, and Gabriele Bergers
Cell of origin and cancer stem cells in tumor suppressor mouse models of Glioblastoma / Sheila R. Alcantara Llaguno, Zuanhua Xie, and Luis F. Parada. Genetics and epigenetics : The enigma of p53 / Guillermina Lozano
Alterations in three-dimensional organization of the cancer genome and epigenome / Joanna Achinger-Kawecka, Phillippa C. Taberlay, and Susan J. Clark
COmposition and function of mammalian SWI/SNF chromatin remodeling complexes in human disease / John L. Pulice and Cigall Kadoch
The essential transcriptional function of BRD4 in acute myeloid leukemia / Jae-Seok Roe and Christopher R. Vakoc. Metabolism : Reexamining how cancel cells exploit the body's metabolic resources : Craig B. Thompson and Wilhelm Palm
Autophagy, metabolism, and cancer / Jessie Yanxiang Guo and Eileen White
A time for MYC: metabolism and therapy / Chi V. Dang
Beyond the oncogene revolution: four new ways to combat cancer / Thorsten Berger, Mary E. Saunders, and Tak W. Mak
Lipid synthesis is a metabolic liability of non-small cell lung cancer / Robert U. Svensson and Reuben J. Shaw. Targets, vaccines, and therapeutics : Cancer immunogenomics: computational neoantigen identification and vaccine design / Jasreet Hundal, Christopher A. Miller, Malachi Griffith, Obi L. Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua McMichauel, Adam Coffman, and Elaine R. Mardis
Targeting HIF2 in clear cell renal cell carcinoma / Hyejin Cho and William G. Kaelin
BET bromodomain proteins as cancer therapeutic targets / Shaokun Shu and Kornelia Polyak
To prime, or not to prime: that is the question / Danielle S. Potter and Anthony Letai
Genetic dissection of cancer development, therapy response, and resistance in mouse models of breast cancer / Stefano Annunziato, Marco Barazas, Sven Rottenberg, and Jos Jonkers. Microenvironment and metastasis : Tumor-stroma interactions in bone metastasis: molecular mechanisms and therapeutic implications / Hanqiu Zheng, Wenyang Li, and Yibin Kang
Cancer, oxidative stress, and metastasis / Jennifer G. Gill, Elena Piskounova, and Sean J. Morrison
RON signaling is a key mediator of tumor progression in many human cancers / Najme Faham and Alana L. Welm
Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis / Madeleine J. Oudin and Valerie M. Weaver. Models of cancer : Pathways involved in formation of mammary organoid architecture have keys to understanding drug resistance and to discovery of druggable targets / Saori Furuta and Mina J. Bissell
Explaining the paucity of intratumoral T cells: a construction out of known entities / Douglas T. Fearon
Modeling breast cancer intertumor and intratumour heterogeneity using xenografts / Alejandra Bruna, Oscar M. Rueda, and Carlos Caldas
Challenges and opportunities in modeling pancreatic cancer / Michael E. Feigin and David A. Tuveson. Cancer genomics and tumor heterogeneity : Functional genomic characterization of cancer genomes / Thomas P. Howard, Francisca Vazquez, Aviad Tsherniak, Andrew L. Hong, Mik Rinne, Andrew J. Aguirre, Jesse S. Boehm, and William C. Hahn
How cancer genomics drives cancer biology: does synthetic lethality explain mutually exclusive oncogenic mutations? / Harold Varmus, Arun M. Unni, and William W. Lockwood
A pipeline for drug target identification and validation / Eusebio Manchado, Chun-Hao Huang, Nilgun Tasdemir, Darjus F. Tschaharganeh, John E. Wilkinson, and Scott W. Lowe
SIngle-cell analysis of circulating tumor cells as a window into tumor heterogeneity ? David T. Miyamoto, David T. Ting, Mehmet TOner, Shyamala Maheswaran, and Daniel A. Haber
Discovery of double-stranded genomic DNA in circulating exosomes / Raghu Kalluri and Valerie S. LeBleu. Summary : Moving closer to victory / Taru Muranen and Joan S. Brugge. Dorcas Cummings lecture : Charles Sawyers. Conversations at the symposium : Gabriele Bergers
Joan Brugge
Karen Cichowski
Susan Clark
Gerard Evan
Daniel Haber
William Kaelin
Raghu Kalluri
Scott Lowe
Guillermina (Gigi) Lozano
David Lyden
Elaine Mardis
Sean Morrison
Benjamin Neel
Luis Parada
Sir Michael Stratton
David Tuveson
Christopher Vakoc
Harold Varmus
Karen Vousden
Valerie Weaver
Robert Weinberg
Eileen White. Author index. Subject index.