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  • Book
    edited by Ruth Lyck, Gaby Enzmann.
    Summary: Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.

    Contents:
    General Introduction to Barrier Mechanisms in the Central Nervous System
    Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research
    The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions
    Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases
    Leakage at Blood-neural Barriers
    Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology
    MicroRNAs in Brain Endothelium and Inflammation
    Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases
    Pathways Across the Blood Brain Barrier
    Neuroinflammation in Bacterial Meningitis
    Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.
    Digital Access Springer 2017
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2017
    QP375.5 .B56 2017
    1