BookLang Tran, Miguel A. Bañares, Robert Rallo, editors.
Summary: In today's nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.
Contents:
Engineering nanomaterials: their physicochemical characteristics and how to measure them
Assessment of human exposure to ENMs
The life cycle of engineered nanoparticles
From dose to response: in vivo nanoparticle processing and potential toxicity
Literature review of (Q)SAR modelling of nanomaterial toxicity
Systems biology to support nanomaterial grouping
Multiscale modelling of bionano interface
Biological surface adsorption index of nanomaterials: modelling surface interactions of nanomaterials with biomolecules
An integrated data-driven strategy for safe-by-design nanoparticles: the FP7 MODERN project
Compilation of data and modelling of nanoparticle interactions and toxicity in the NanoPUZZLES project
Case study III: the construction of a nanotoxicity database, the MOD-ENP-TOX experience.
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