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  • Book
    John Varga, Christopher P. Denton, Fredrick M. Wigley, Yannick Allanore, Masataka Kuwana, editors.
    Summary: Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

    Section I. Introduction
    Historical Perspective of Scleroderma
    Section II. Epidemiology, Genetics and Classification
    Epidemiology, Environmental and Infectious Risk Factors
    Genetic Factors
    Disease Subsets in Clinical Practice
    Evolving Concepts of Diagnosis and Classification
    Overlap Syndromes
    Juvenile Localized and Systemic Scleroderma
    Morphea (Localized Scleroderma)
    Scleroderma Mimics
    Systems Biology Approaches to Understanding the Pathogenesis of Systemic Sclerosis
    Section III: The Biological Basis of Systemic Sclerosis
    Introduction: The Etiopathogenesis of Systemic Sclerosis: An Integrated Overview
    Pathology of Systemic Sclerosis
    Inflammation and Immunity
    Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis
    The Clinical Aspects of Autoantibodies
    Mechanisms of Vascular Disease
    Biomarkers in Systemic Sclerosis
    Pathophysiology of Fibrosis in Systemic Sclerosis
    Overview of Animal Models
    Section IV. Cardiovascular Manifestations and Management
    Raynaud's Phenomenon, Digital Ulcers, and Nailfold Capillaroscopy
    Renal Crisis and Other Renal Manifestations of Scleroderma
    Cardiac Involvement
    Section V. Pulmonary Manifestations and Management
    Overview of Lung Involvement: Diagnosis, Differential Diagnosis, and Monitoring
    Clinical Assessment of Lung Disease
    Treatment of Interstitial Lung Disease
    Pathogenesis of Pulmonary Arterial Hypertension
    Clinical Assessment of Pulmonary Hypertension
    The Management of Pulmonary Arterial Hypertension in the Setting of Systemic Sclerosis
    Section VI. Gastrointestinal Manifestations and Management
    Overview of Gastrointestinal Tract Involvement
    Upper Gastrointestinal Tract: Manifestations of Systemic Sclerosis
    Small and Large Intestinal Involvement and Nutritional Issues
    Section VII. Skin, Musculoskeletal and Other Complications
    Evaluation and Management of Skin Disease
    Assessment and Management of Progressive Skin Involvement in Diffuse Scleroderma
    Skeletal Muscle Involvement
    Tendons, Joints, and Bone
    Cancer in Systemic Sclerosis
    Overlooked Manifestations
    Section VIII: Management and Outcome Assessment
    Introduction to Section VIII: Management and Outcome Assessment
    Immunomodulatory, Immunoablative, and Biologic Therapies
    Investigative Approaches to Drug Therapy
    Drug Development and Regulatory Considerations for SSc Therapies
    Physical and Occupational Therapy
    Psychosocial Issues and Care for Patients with Systemic Sclerosis
    Clinical Trial Design in Systemic Sclerosis
    Measuring Disease Activity and Outcomes in Clinical Trials
    Innovative Approaches to Clinical Trials in Systemic Sclerosis
    Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis
    Section IX. Case Studies: Approach to Complex Clinical Problems
    Managing the Ischemic Finger in Scleroderma
    Scleroderma Renal Crisis
    Rapid Diffuse Skin Disease with Progressive Joint Contractures
    Management of the Scleroderma Patient with Pulmonary Arterial Hypertension Failing Initial Therapy
    Pseudo-obstruction with Malabsorption and Malnutrition
    Progressive Interstitial Lung Disease Non-Response to Cyclophosphamide
    Coping with the Disfigurement of Scleroderma: Facial, Skin, and Hand Changes
    Managing Complicated Digital Ulcers .
    Digital Access Springer 2017