BookLuigi Pirtoli, Giovanni Luca Gravina and Antonio Giordano, editors.
Contents:
Introduction and Background
The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options
Radiobiological Hints from Clinical Studies
Chemo-radiotherapy: Radiation Total Dose and Fractionation
Clinical Evidence and Radiobiological Background of Particle Radiation Therapy
Mathematical Modeling of Radiobiological Parameters from Clinical Studies
Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series
Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond
Basic Knowledge of Glioblastoma Radiobiology
Molecular Radiobiology and Mathematical Modeling
Genetic and Epigenetic Determinants in Tumor Initiation and Progression
Tumor Microenvironment
Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy
mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models
Glioma Stem-like Cells and Radiation Resistance
Hypoxia and Radiation Resistance
Invasiveness and Radiation Failures
Nanoparticle Technology for Research Radiobiology
The Molecular Classification of Glioblastoma as a Translational Instrument
Translational Perspectives for Gene Therapy
Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods
From Molecular to Clinical Radiation Biology
Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results
Conclusive Remarks and Perspectives for Future Research.