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- Bookedited by Xiangdong Wang, Christian Baumgartner, Denis C. Shields, Hong-Wen Deng, Jacques S Beckmann.Contents:
The Era of Big Data: From Data-driven Research to Data-driven Clinical Care
Biostatistics, data mining and computational modeling
Gene expression and profiling
The next generation sequencing and applications in clinical research
Clinical epigenetics and epigenomics
Proteomic profiling: Data mining and analyses
Targeted metabolomics: the next generation of clinical chemistry!?
Clinical bioinformatics for biomarker discovery in targeted metabolomics
Metagenomic Profiling, Interaction of Genomics with Meta-genomics
Clinical Epigenetics and Epigenomics
Integrative Biological Databases
Standards and Regulations for (Bio)Medical Software
Clinical applications and systems biomedicine
Key Law and Policy Considerations for Clinical Bioinformaticians
Challenges and Opportunities in Clinical Bioinformatics
Heterogeneity of Hepatocellular Carcinoma. - ArticleEllis FP.Trans R Soc Trop Med Hyg. 1976;70(5-6):412-8.The effects of elevated temperatures and the time-temperature combinations for irreversible damage are outlined. Coagulation abnormalities and the effects on the kidney, liver, heart, brain and serum enzymes, the role of electrolytes and water, including salt deficiency and the controversial question of salt supplements, potassium deficiency, changes in other electrolytes and sweat solutes, and rhabdomyolysis (including a discussion of experimental work on dogs) are reviewed. The section ends with a discussion of the effects of drugs and an account of a recent fatal case of heat stroke which may have been triggered by chlorpromazine therapy.