Bookedited by Hanns-Christian Mahler, Wim Jiskoot.
Contents:
The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins
Separation based analytical methods for measuring protein aggregation
Laser light scattering-based techniques used for the characterization of protein therapeutics
Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals
Analytical methods to measure sub-visible particulates
Detection of visible particles in parenteral products
Characterization of aggregates and particles using emerging techniques
Ultraviolet absorption spectroscopy
Fluorescence spectroscopy to characterize protein aggregates and particles
Infrared spectroscopy to characterize protein aggregates
Raman microscopy for characterization of particles
Microscopic methods for particle characterization in protein pharmaceuticals
Comparison of methods for soluble aggregate detection and size characterization
Protein purification and its relation to protein aggregation and particles
Formulation development and its relation to protein aggregation and particles.