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  • Book
    Omar M.E. Abdel-Salam, editor.
    Summary: This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors, and gastrointestinal, dermatologic, and urologic disorders. It discusses the basic functions of the capsaicin receptor (TRPV1), its mechanisms of action, and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research.

    Contents:
    Capsaicin and Sensory Neurones: a Historical Perspective
    Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type 1 Ion Channel
    TRPV1 in the Central Nervous System: Synaptic Plasticity, Function and Pharmacological Implications
    Topical Capsaicin Formulations in the Management of Neuropathic Pain
    Capsaicin-Based Therapies for Pain Control
    Intranasal Capsaicin in Management of Non-allergic (Vasomotor) Rhinitis
    Capsaicin as an Anti-obesity Drug
    The Potential Antitumour Effects of Capsaicin
    Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Non-Steroidal Anti-inflammatory Drugs in Human Healthy Subjects and in Patients
    Calcitonin Gene-Related Peptide as Target of Capsaicin Receptor in the Gut
    Capsaicin for Osteoarthritis Pain
    The Role of Capsaicin in Dermatology
    Use of Vanilloids in Urologic Disorders.
    Digital Access Springer 2014
  • Article
    Whiteside TL.
    Am J Pathol. 1977 Jan;86(1):1-16.
    Specific anti-human T-cell serum was prepared in rabbits by multiple subcutaneous injections of human brain homogenates in incomplete Freund's adjuvant. The serum was exhaustively absorbed with human RBCs, lyophilized human liver, lyophilized normal human serum, and peripheral blood lymphocytes from patients with chronic lymphocytic leukemia (CLL). Specificity of the antiserum for human T lymphocytes was tested by indirect immunofluorescence. It stained 70 to 80% of lymphocytes in circulation, 95% of thymus, 27 to 35% of spleen, 5 to 10% of tonsil lymphocytes, and over 90% of phytohemagglutinin-stimulated lymphocytes in vitro. Only T-dependent areas of cryostat-sectioned human lymph nodes stained with the antiserum. It did not stain circulating lymphocytes which formed HEAC rosettes, plasma cells in marrows of multiple myeloma patients or macrophages. After removal of HEAC rosettes by centrifugation in Ficoll-Hypaque, 75% of interface cells formed E rosettes and 65 to 75% stained with the antiserum. The antiserum was used in studies of lymphocytes in chronic and acute lymphocytic leukemias, lymphomas, and other lymphoproliferative diseases. Numbers and distribution in the circulation, spleen and nodes of lymphocytes bearing the T marker were significantly altered in patients with these disorders.
    Digital Access Access Options