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  • Book
    Jen-Chywan Wang, Charles Harris, editors.
    Summary: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.

    Contents:
    Section I: Introductory Materials
    Regulatory actions of glucocorticoid hormones: from organisms to mechanisms.- Molecular Biology of Glucocorticoid Signaling.-Mechanisms of Glucocorticoid-regulated Gene Transcription
    Clinical Perspective: What do Addison and Cushing tell us about Glucocorticoid Action?
    Section II: Effects of Glucocorticoids in Metabolism
    Regulation of Glucose Homeostasis by Glucocorticoids
    How do Glucocorticoids Regulate Lipid Metabolism?
    Glucocorticoids and Skeletal Muscle
    Section III: Specific Effects of Glucocorticoids on Tissues
    Glucocorticoid- induced osteoporosis
    Effects of Glucocorticoids on Immune System
    Glucocorticoids and the brain: neural mechanisms regulating the stress response
    Glucocorticoid Regulation of Reproduction
    Glucocorticoids and the lung
    Glucocorticoids and the Cardiovascular System
    Glucocorticoids and Cancer
    Section IV: Miscellaneous Topics
    Animal Models of Altered Glucocorticoid Signaling
    The Dehydrogenase Hypothesis
    Conclusions and Future Directions.
    Digital Access Springer 2015