BookJeremy Nuttall, editor.
Summary: One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
Contents:
Candidate Microbicides and Their Mechanisms of Action
Microbicide Dosage Forms
Preclinical Safety Evaluation
Clinical Safety and Pharmacology Trial
Microbicides for Prevention of HIV Infection: Clinical Efficacy Trials
Rectal Microbicide Development
Developing Regulatory Strategy for Microbicides
Preparing for Microbicide Introduction, Rollout and Sustained Access.
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