Book[edited by] M.A. Hayat.
Summary: Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types - lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.
Contents:
Brain metastasis from solid tumors
The role of surgical resection for metastatic brain tumors
Whole-brain radiotherapy for brain metastases: is the therapeutic window enlarging?
Brain metastasis in patients with non-small cell lung cancer: response to epidermal growth factor receptor tyrosine kinase inhibitors
Brain metastasis from non-small cell lung cancer: use of epidermal growth factor receptor and HER2 status for targeted therapy
Brain metastases from non-small cell lung cancer: current evidence in management using tyrosine kinase inhibitor and whole-brain radiation therapy
Brain metastasis in patients with non-small cell lung cancer: immunohistochemical markers
Brain metastasis from breast cancer: molecular mechanisms
New targeted therapies for brain metastases from breast and lung cancer and melanoma
Breast cancers with brain metastases
Brain metastases in melanoma patients: treatment with adjuvant postoperative whole-brain radiotherapy
Melanoma progression in the brain: role of pericytes, the basal lamina, and endothelial cells in tumor vascularization
Brain metastases from esophageal cancer in the presence of HER-2 overexpression
Brain metastasis from renal carcinoma: locoregional and systemic treatments
Gastrointestinal cancer and brain metastasis outcomes and management
Brain metastasis of colorectal cancer: microenvironment and molecular mechanism
Brain metastasis from nasopharyngeal carcinoma.