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  • Book
    James S. Lowe, Peter G. Anderson.
    Contents:
    Histology
    The cell
    Epithelial cells
    Support cells and the extracellular matrix
    Contractile cells
    Nervous tissue
    Blood cells
    Immune system
    Blood and lymphatic circulatory systems and heart
    Respiratory system
    Alimentary tract
    Liver
    Musculoskeletal system
    Endocrine system
    Urinary system
    Male reproductive system
    Female reproductive system
    Skin and breast
    Special senses.
    Digital Access ScienceDirect 2015
  • Article
    Konings AW, Damen J, Trieling WB.
    Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Apr;35(4):343-50.
    Liposomes were prepared from phospholipids extracted from biological membranes. A comparison was made between the peroxidation rate in handshake liposomes and in sonicated liposomes. The smaller sonicated liposomes were more vulnerable to peroxidation, probably because of the smaller radius of curvature, which results in a less dense packing of lipid molecules in the bilayer and a facilitated action of water radicals produced by the X-irradiation. High oxygen enhancement ratios were obtained, especially at low dose rates, suggesting the operation of slowly progressing chain reactions initiated by ionizing radiation. Three compounds were tested for their ability to protect the liposomal membranes against lipid peroxidation. The naturally occurring compounds reduced glutathione (GSH) and vitamin E(alpha-T) and the powerful radiation protector cysteamine (MEA). All three molecules could protect the liposomes against peroxidation. The membrane-soluble compound vitamin E was by far the most powerful. About 50 per cent protection was achieved by using 5 X 10(-6) M alpha-T, 10(-4) M GSH and 5 X 10(-4) M MEA. The fatty acid composition of the lipids altered drastically as a result of the irradiation. Arachidonic acid and docosahexanoic acid were the most vulnerable of the fatty acids. Very efficient protection of these polyunsaturated fatty acids could be obtained with relatively low concentrations of vitamin E built into the membranes.
    Digital Access Access Options