BookRonald Gieschke, Daniel Serafin.
Summary: The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?
Contents:
Background of pharmacologic modeling
First example of a computational model
Differential equations in MATLAB
Pharmacologic modeling
Drug-disease modeling
Population analyses
Clinical trial simulation
Graphics-based modeling
Outlook
Appendix A: Hints to MATLAB programs
Appendix B: Solution to exercises.