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  • Book
    Andreas Burkovski, editor.
    Summary: Corynebacterium diphtheriae is the classical etiological agent of diphtheria and the type strain of the genus Corynebacterium. While diphtheria of the respiratory tract became rare with the introduction of vaccination programs in industrialized countries, even today several thousand cases per year are reported to the World Health Organization. This shows that diphtheria is not completely eradicated and that reservoirs exist. The book summarizes the latest advances made in understanding C. diphtheriae and the closely related species Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Topics addressed are genomics of toxigenic corynebacteria, host-pathogen-interaction, detection, surveillance and treatment as well as application aspects.

    Contents:
    Diphheria and its etiological agents
    Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis
    general aspects
    Comparative genomics and pathogenicity islands of Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis
    Corynephages : infections of the infectors
    toxin structure, delivery and action
    Iron acquisition and iron-dependent gene expression in Corynebacterium diphtheria
    Assembly and function of Corynebacterium diphtheria
    Toxigenic Corynebacteria : adhesion, invasion and host response
    Detection methods for laboratory diagnosis of Diphtheria
    Diphtheria surveillance
    History of diphtheria vaccine development
    Antimicrobial susceptibility and treatment
    Sialidases of Corynebacteria and their biotechnological application
    Molecular genetic tools for research in Corynebacterium diphtheria
    Diphtheria toxin based molecules as therapeutic approaches.
    Digital Access Springer 2014