Booksymposium organizers and proceedings editors Anne O'Garra, Michel Nussenzweig, Stephen Smale, and David Stewart and Bruce Stillman.
Contents:
Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre
Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh
The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky
Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt
The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi
T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss
NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian
Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis
Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky
miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu
Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky
Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.