BookTasuku Harada, editor.
Summary: Endometriosis is one of the most common gynecological diseases, causingpelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight intothe pathogenesis and pathophysiology of endometriosis-essentialinformation forcliniciansintending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.
Contents:
Preface
PART I. INTRODUCTION
Endometriosis: a mysterious disease
Part II. BASIC SCIENCE
Pathological aspect and pathogenesis of endometriosis
Visible and invisible (occult) endometriosis
Role of stem cells in the pathogenesis of endometriosis
Role of NK cells in endometriosis
Macrophages in Pathophysiology of Endometriosis
Inflammation and Cytokines in Endometriosis
Epigenetics in endometriosis
Roles of Prostaglandin E2 in Endometriosis
Sex steroids and endometriosis
Aromatase expression in endometriosis and its significance
Apoptosis in Endometriosis
Role of nerve fibres in endometriosis
Endometriosis in experimental models
Malignant transformation of endometriosis
underlying mechanisms
Potential new drugs for endometriosis: experimental evidence
Altered Biological Characteristics of Eutopic and Ectopic Endometrium
PartIII. CLINICAL SCIENCE
Prevention of Endometriosis
MR imaging of endometriosis
Biomarkers of endometriosis
Classification of Endometriosis
The Association of Endometriosis with Ovarian Cancer: A Critical Review of Epidemiological Data
Surgical management of endometriosis
Systematic laparoscopic surgery of complete obliteration of the cul-de-sac
Prevention of recurrence after surgery
Ovarian reserve in patients with endometriosis
Infertility treatment of endometriosis patients
Pregnancy complications associated with endometriosis
Malignant transformation of endometriosis.