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    Ali Mobasheri [and others].
    Summary: Articular cartilage is a unique and highly specialized avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an essential source of energy during embryonic growth and fetal development and is vital for mesenchymal cell differentiation, chondrogenesis and skeletal morphogenesis. Glucose is an important metabolic fuel for differentiated chondrocytes during post-natal development and in adult articular cartilage and is a common structural precursor for the synthesis of extracellular matrix glycosaminoglycans.

    Contents:
    Introduction
    Articular cartilage: structure, function and pathophysiology
    Does arthritis have a nutritional aetiology?
    Metabolic dysfunction in arthritis
    Glucose: an essential metabolite and structural precursor for articular cartilage
    Mammalian sugar transporter families: GLUT and SGLT
    Molecular diversity of facilitative glucose transporters in articular chondrocytes
    Regulation of glucose transport by non-steroidal anti-inflammatory drugs (NSAIDs)
    Glucose transporters in the intervertebral disc
    Glucose transporter expression and regulation in embryonic and mesenchymal stem cells
    Concluding remarks.
    Digital Access Springer 2008