BookKumar Selvarajoo.
Summary: Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches.
Contents:
Systems biology of population cell response
Perturbation-response approach for biological network analysis
Basics of the mammalian immune system
Inferring novel features of the TLR4 pathways
Signaling Flux Redistribution
Investigating the TLR3 signaling dynamics
Understanding TNFR1 signaling dynamics
TRAIL signaling in cancer
Stochasticity and variability: insights from single cell dynamics
Investigating single cell stochasticity in TRAIL signaling
The distinction between single cell and population dynamics
Finding chaos in biology
Concluding remarks.