BookStefan Grimm, editor.
Summary: "This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as "Anticancer Genes", are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells."--Publisher's website.
Contents:
1. Introduction / Stefan Grimm
Part I. Viral Anticancer Genes
2. Signalling of Apoptin / Jessica Bullenkamp and Mahvash Tavassoli
3. Apoptin Towards Safe and Efficient Anticancer Therapies / Claude Backendorf and Mathieu H.M. Noteborn
4. Induction of Cancer-Specific Cell Death by the Adenovirus E4orf4 Protein / Tamar Kleinberger
5. Tumor Suppressing Properties of Rodent Parvovirus NS1 Proteins and Their Derivatives / Jürg P.F. Nüesch and Jean Rommelaere
Part II. Cellular Anticancer Genes
6. MDA-7/IL-24: Multifunctional Cancer Killing Cytokine / Mitchell E. Menezes, Shilpa Bhatia, Praveen Bhoopathi, Swadesh K. Das, Luni Emdad, Santanu Dasgupta, Paul Dent, Xiang-Yang Wang, Devanand Sarkar, and Paul B. Fisher
7. Cancer-Selective Apoptosis by Tumor Suppressor Par-4 / Nikhil Hebbar, Tripti Shrestha-Bhattarai, and Vivek M. Rangnekar
8. Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) / Simone Fulda
9. SIRT6: A Promising Target for Cancer Prevention and Therapy / Michael Van Meter, Vera Gorbunova, and Andrei Seluanov
10. An Overview of Brevinin Superfamily: Structure, Function and Clinical Perspectives / Anna Savelyeva, Saeid Ghavami, Padideh Davoodpour, Ahmad Asoodeh, and Marek J. Łos
11. Isolation and Characterization of the Anticancer Gene Organic Cation Transporter Like-3 (ORCTL3) / Ghada AbuAli and Stefan Grimm
Part III. Anticancer Gene Therapy
12. Introduction of Genes via Sonoporation and Electroporation / Christina Kalli, Wey Chyi Teoh, and Edward Leen
13. Anticancer Gene Transfer for Cancer Gene Therapy / Evangelos Pazarentzos and Nicholas D. Mazarakis.
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