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  • Book
    Helen E. Scharfman, Paul S. Buckmaster, editors.
    Contents:
    Part 1. How can we identify ictal and interictal abnormal activity? / Robert S. Fisher, Helen E. Scharfman, and Marco deCurtis
    What is the clinical relevance of in vitro epileptiform activity? / Uwe Heinemann and Kevin J. Staley
    What is the importance of abnormal "background" activity in seizure generation? / Richard J. Staba and Gregory A. Worrell
    What is a seizure focus? / J. Victor Nadler and Dennis D. Spencer
    What is a seizure network? Long-range network consequences of focal seizures / Hal Blumenfeld
    What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain / Roger D. Traub, Mark O. Cunningham, and Miles A. Whittington
    Is there such a thing as "generalized" epilepsy? / Gilles van Luijtelaar, Charles Behr, and Massimo Avoli
    Part 2. Are there really "epileptogenic" mechanisms or only corruptions of "normal" plasticity? / Giuliano Avanzini, Patrick A. Forcelli, and Karen Gale
    When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? / Ray Dingledine, Nicholas H. Varvel, and F. Edward Dudek
    How is homeostatic plasticity important in epilepsy? / John W. Swann and Jong M. Rho
    Is plasticity of GABAergic mechanisms relevant to epileptogenesis? / Helen E. Scharfman and Amy R. Brooks-Kayal
    Do structural changes in GABA neurons give rise to the epileptic state? / Carolyn R. Houser
    Does mossy fiber sprouting give rise to the epileptic state? / Paul S. Buckmaster
    Does brain inflammation mediate pathological outcomes in epilepsy? / Karen S. Wilcox and Annamaria Vezzani
    Are changes in synaptic function that underlie hyperexcitability responsible for seizure activity? / John G.R. Jefferys
    Does epilepsy cause a reversion to immature function? / Aristea S. Galanopoulou and Solomon L. Moshé
    Are alterations in transmitter receptor and ion channel expression responsible for epilepsies? / Kim L. Powell, Katarzyna Lukasiuk, Terence J. O'Brien, and Asla Pitkänen
    Part 3. How do we make models that are useful in understanding partial epilepsies? / David A. Prince
    Aligning animal models with clinical epilepsy: where to begin? / Stephen C. Harward and James O. McNamara
    What non-neuronal mechanisms should be studied to understand epileptic seizures? / Damir Janigro and Matthew C. Walker
    What epilepsy comorbidities are important to model in the laboratory? clinical perspectives / Simon Shorvon
    Epilepsy comorbidities: how can animal models help? / Carl E. Stafstrom
    What new modeling approaches will help us identify promising drug treatments? / Scott C. baraban and Wolfgang Löscher
    What are the arguments for and against rational therapy for epilepsy? / Melissa Barker-Haliski, Graeme J. Sills, and H. Steve White
    How can advances in epilepsy genetics lead to better treatments and cures? / Renzo Guerrini and Jeffrey Noebels
    How might novel technologies such as optogenetics lead to better treatments in epilepsy? / Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz, and Merab Kokaia
    Index.
    Digital Access Springer 2014