Bookedited by Marcus Groettrup.
Summary: To cope with the steadily growing body of knowledge and for organizational reasons the articles in this book are focussed on the modifiers ubiquitin, SUMO1/2/3, NED 8, ISG15 and FAT10 but it should be at least mentioned here that enzymes involved in conjugation and deconjugation of URM1, UFM1, ATG8 and ATG12 have been reported and continue to be investigated.
Contents:
Activation of ubiquitin and ubiquitin-like proteins / Frederick C. Streich Jr. and Arthur L. Haas
Control of ubiquitin conjugation by CDC48 and its cofactors / Alexander Buchberger
Regulation of ubiquitin receptors by coupled monoubiquitination / Daniela Hoeller and Ivan Dikic
Control of cullin-ring ubiquitin ligase activity by Nedd8 / Raymond J. Deshaies, Ethan D. Emberley, and Anjanabha Saha
Control of deneddylation by the COP9 signalosome / Tilo Schmaler and Wolfgang Dubiel
Mechanism, specificity, and structure of the deubiquitinases / David Komander
Ubiquitin conjugation and deconjugation in Nf-kB signaling / Michael Düwel, Kamyar Hadian, and Daniel Krappmann
Functions of linear ubiquitin chains in the Nf-kB pathway : linear polyubiquitin in Nf-kB signaling / Kazuhiro Iwai
Assembly of K11-linked ubiquitin chains by the anaphase promoting complex / Michael Rape
Ubiquitin family members in the regulation of the tumor suppressor p53 / Dimitris P. Xirodimas and Martin Scheffner
Ubiquitylation in the ERAD pathway / Frederik Eisele, Antje Schäfer, and Dieter H. Wolf
Pupylation : a signal for proteasomal degradation in mycobacterium tuberculosis / Kristin E. Burns and K. Heran Darwin
SUMO control / Katharina Maderböck and Andrea Pichler
The in vivo functions of desumoylating enzymes / Tasneem Bawa-Khalfe and Edward T.H. Yeh
Regulatory functions of ubiquitin and SUMO in DNA repair pathways / Stefan Jentsch and Stefan Müller
Sumoylation as a signal for polyubiquitylation and proteasomal degradation / Maria Miteva ... [et al.]
In vivo functions of isgylation / Klaus-Peter Knobeloch
Identification and validation of ISG15 target proteins / Larissa A. Durfee and Jon M. Huibregtse
FAT10 : activated by UBA6 and functioning in protein degradation / Christiane Pelzer and Marcus Groettrup.