BookRandy L. Jirtle, Frederick L. Tyson, editors.
Summary: The capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming.
Contents:
Epigenetic Programming of the Brain
Epigenetics and Maternal Brain Evolution / Eric B. Keverne
Social Environment and DNA Methylation: A Mechanism for Linking Nurture and Nature / Moshe Szyf
Sex Differences in Epigenetic Programming of Brain Differentiation: Implications for Mental Health and Disease / Anthony P. Auger, Catherine J. Auger
Epigenetics and Neurological Disorders
Phenotypic Plasticity, Pleiotropy, and the Growth-First Theory of Imprinting / Jon F. Wilkins
The Imprinted Brain: How Genes Set the Balance Between Autism and Psychosis / Christopher Badcock
Epigenetics at the Interface of Genetics and Environmental Factors in Autism / Janine M. LaSalle, Roxanne O. Vallero, Michelle M. Mitchell
Epigenomic and Noncoding RNA Regulation in Addictive Processes / John S. Satterlee
Epigenetic Therapies in Neurological Diseases / Hsien-Sung Huang, Benjamin D. Philpot, Yong-hui Jiang
Epigenetics, Nutrition, Diabetes, and Obesity
Nutrition, Histone Epigenetic Marks, and Disease / Janos Zempleni, Dandan Liu, Jing Xue
Chromatin Switching and Gene Dynamics Associated with Type 2 Diabetes / Ian C. Wood
Developmental Epigenetic Programming in Diabetes and Obesity / Caroline L. Relton, George Davey-Smith, Susan E. Ozanne
Epigenetics and Cancer
Developmental Reprogramming by Environmental Estrogens: How Early Life Exposures Affect Cancer Risk in Adulthood / Cheryl L. Walker
Human Cancer Epigenetics / F. Javier Carmona, Manel Esteller
Epigenetics and the Law
Legal and Ethical Implications of Epigenetics / Mark A. Rothstein.