BookRandy L. Jirtle, Frederick L. Tyson, editors.
Summary: Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.
Contents:
Fetal Origins of Adult Disease Susceptibility
Epigenetics: How Genes and Environment Interact / Randy L. Jirtle
Developmental Epigenomics and Metabolic Disease / Peter D. Gluckman, Felicia M. Low, Mark A. Hanson
Sculpting Our Future: Environmental Nudging of the Imprintome / Susan K. Murphy, Cathrine Hoyo
Epigenetics and Environmental Exposures
Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures / Christopher Faulk, Dana C. Dolinoy
Epigenetic Effects of Ionizing Radiation / Olga Kovalchuk
The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury / Kenneth S. Ramos ... [et al.]
Epigenetics, Gene Regulation, and Stem Cells
Environmental Impact on Epigenetic Histone Language / John M. Denu
Chromatin Structure and Gene Expression: Function Follows Form / Aleksandra B. Adomas, Paul A. Wade
Epigenetics of Pluripotency / R. David Hawkins, Bing Ren
Epigenetic Transgenerational Inheritance
Transgenerational Epigenetic Inheritance in Drosophila / Luan Wang, Xiangyi Lu, Douglas M. Ruden
Environmental Epigenetics and Epigenetic Transgenerational Inheritance / Michael K. Skinner
The Nature of Human Transgenerational Responses / Marcus E. Pembrey, Lars O. Bygren, Jean Golding.