BookFedor Berditchevski, Eric Rubinstein, editors.
Summary: Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.
Contents:
Structural bases for tetraspanin funtions
The evolution of tetraspanins through a phylogenetic lens
Organisation of the tetraspanin web
Dynamic partitioning of tetraspanins within plasma membranes
Tetraspanins as regulators of protein trafficking
The role of tetraspanins in cell migration and intercellular adhesion
Genetic evidence for tetraspanin functions
Tetraspanins in lower eukaryotes
The role of tetraspanin complexes in egg-sperm fusion
Tetraspanins and immunity
Tetraspanins in cancer
Uroplakins as unique tetraspanin networks
Essential tetraspanin functions in the vertebrate retina
The role of CD81 in HCV and plasmodium infection
Tetraspanins as facilitators of viral and cellular information transfer.