BookKerry L. Tucker, Tamara Caspary, editors.
Summary: Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as 'antennae' for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.
Contents:
Primary and Motile Cilia: Their Ultrastructure and Ciliogenesis / Sigrid Hoyer-Fender
Primary Cilia, Sonic Hedgehog Signaling, and Spinal Cord Development / Laura E. Mariani, Tamara Caspary
Primary Cilia and Brain Development / Evangelia Tasouri, Marc August Willaredt
Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal Cells / Matthew R. Sarkisian, Jon I. Arellano
Primary Cilia and Inner Ear Sensory Epithelia / Cynthia M. Grimsley-Myers, Ping Chen
Neuronal Cilia and Obesity / Nicolas F. Berbari, Raymond C. Pasek
Motile Cilia and Brain Function: Ependymal Motile Cilia Development, Organization, Function and Their Associated Pathologies / Nathalie Spassky
Primary Cilia and Brain Cancer / Shirui Hou, Young-Goo Han
Abnormalities of the Central Nervous System Across the Ciliopathy Spectrum / Kate Baker, Philip L. Beales.