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- Book[lead authors/editors, Michael S. Manley, Leslie D. Manley].Contents:
General principles
Behavioral science
Biochemistry
Molecular biology, genetics, and cell biology
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The hematologic and lymphoreticular system. - ArticleKozarevic D, Laban M, Budimir M, Vojvodic N, Roberts A, Gordon T, McGee DL.Am Rev Respir Dis. 1978 Jun;117(6):1039-43.As part of a larger investigation of factors associated with chronic obstructive pulmonary disease among Yugoslavian men, an attempt was made to measure the role played by alpha1-antitrypsin deficiency in the causation of those diseases. Almost 3,000 men from Tuzla, an industrial and mining center in central Bosnia, were screened for alpha1-antitrypsin deficiency. Twenty-six men heterozygous for the Pi MZ phenotype were found in this population. The men with the Pi MZ phenotype were compared with a random sample from the total population. The analysis of the data showed that there is an apparent physiologic impairment associated with Pi Z heterozygosity that produces a shift in the relationships between the different lung volumes without over-all hyperinflation, namely, an increase in residual volume at the expense of vital capacity. However, because of the low prevalence of the Pi Z gene, it does not appear to account for much of the high rate of chronic obstructive pulmonary disease found in this population.