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    The first cases of what would later become known as AIDS were reported in the United States in June of 1981. Since then, 1.8 million people in the U.S. are estimated to have been infected with HIV, including over 650,000 who have already died and more than 1.1 million estimated to be living with the disease today. The response to the U.S. epidemic has yielded numerous successes, but challenges remain.