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  • Book
    Bodh I. Jugdutt, editor.
    Summary: This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis; and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists, and internists.

    Contents:
    Changing demographics of the aging population with heart failure and implications for therapy
    Biology of aging and implications for heart failure therapy and prevention
    Hypertension and prevention of diastolic heart failure in the aging population
    Aging and optimal therapy of systolic heart failure in the elderly
    Atrial fibrillation and heart failure in the aging population
    Optimizing therapy of heart failure in the aging population with monitoring in clinics
    Cardiac alterations in aging, hypertension and diastolic heart failure
    Polypharmacy and adverse drug reactions in the aging population with heart failure
    Aging-related changes in vascular biology and implications for heart failure therapy in the aging population
    Biomarkers and optimal management of heart failure in the aging population
    Benefits of Exercise in the elderly
    The RAAS in heart failure: an update on clinical trials and opportunities for therapy
    Aging and diastolic dysfunction {u2013} the interplay of inflammation and extracellular matrix regulation
    Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomes
    Erythropoietin therapy for heart failure
    Role of resistin in heart failure in the elderly
    Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population
    Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapy
    Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodeling
    Biomarkers of cardiovascular aging
    Changes in the heart that accompany advancing age: Humans to molecules
    Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy
    Aging-related changes in telomeres and telomerases and implications for heart failure therapy
    Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications
    Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction
    Calcium handling defects and changes in cardiac function in the aging heart
    Integrins: Implications for aging in heart failure therapy
    Adipokines as novel biomarkers in aging and heart failure
    Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy
    Aging-related changes in mitochondrial function and implication for heart failure therapy
    Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart
    SMP-30 and aging-related cardiac remodeling and heart failure.
    Digital Access Springer 2014
  • Article
    van Vliet AC, ten Kate FJ, Dees J, van Blankenstein M.
    Endoscopy. 1978 May;10(2):89-94.
    Three elderly females presenting with iron deficiency anaemia and faecal loss of blood were found to have a macronodular cirrhosis of the liver and an unusual red spotty appearence of the prepyloric antral mucosa. One patient underwent antral resection and the surgical specimen revealed abnormalities of the (sub)mucosal blood vessels. Anaemia and occult faecal blood loss disappeared after operation. It is suggested that this type of antral vascular abnormality is aetiologically related to hepatic cirrhosis and may represent a gastric equivalent of cutaneous spider angiomata.
    Digital Access Access Options