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  • Book
    Srinivasan Venkataramanujam, Amnon Brzezinski, Sukru Oter, Samuel D. Shillcutt, editors.
    Summary: The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This bookcontains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinsons disease, Alzheimers disease. Additionally, melatonins therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonins antioxidant role in Duchennes muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.

    Contents:
    Melatonin Receptors and Their Role in Human Diseases
    Melatonins Antioxidant Properties: Molecular Mechanisms
    Past, Present and Future of Melatonins Clinical Uses
    Melatonin in Human Cancer: Therapeutic Possibilities
    Melatonin: Its Microbicidal Properties and Clinical Applications
    Melatonin and the Metabolic Syndrome
    Development of Agonists and Antagonists for Melatonin Receptors
    Multiple Facets of Melatonin in Immunity: Clinical Applications
    Melatonin and Immune Function: Clinical Significance
    Circadian Variation of Immune Mechanisms in Lung Cancer and the Role of Melatonin
    Melatonin and Melatonergic Drugs for Therapeutic Use in Breast Cancer
    Melatonin and Malaria: Therapeutic Avenues
    Melatonin's role in human reproduction: recent studies
    Melatonin Treatment and Fertility
    Melatonin and Pain: Therapeutic Applications
    Melatonin in Alzheimers disease: Focus on Neuroprotective Role
    Melatonin in Parkinsons disease and its Therapeutic Potential
    Melatonin and Its Agonists in Sleep Disorders
    Agomelatine in Depressive Disorders
    Melatonin in Mood Disorders and Agomelatines Antidepressant Efficacy
    The Role of Agomelatine in the Treatment of Anxiety Disorders .- Melatonin in the Etiology, Pathophysiology, and Management of Schizophrenia
    Neurobiology of Monoaminergic Neurotransmission and Antidepressants
    Melatonergic Drug - Ramelteon and Its Therapeutic Applications in Insomnia
    Melatonins Neuroprotective Actions on Hippocampal Neurons
    Jet Lag: Use of Melatonin and Melatonergic Drugs
    Sleep, Melatonin and Circadian Rhythmicity in Attention Deficit Hyperactivity Disorder
    Melatonergic Drugs and Their Therapeutic Use in Nasal Polyposis
    Protective Effects of Exogenous Melatonin Against Methotrexate- Induced Intestinal Injury.
    Digital Access Springer 2014