BookEng H. Lo, Josephine Lok, MingMing Ning, Michael J. Whalen, editors.
Summary: Vascular Mechanisms in CNS Trauma focuses on the vascular aspects of brain and spinal cord trauma.Twenty nine chapters are arranged in three sections:Molecular Mechanisms; Experimental Models and Methods; and Clinical Challenges and Opportunities. The first section addresses topics in the basic biology of brain and spinal cord trauma, ranging from the pathophysiology of cerebral endothelial cells and gliovascular interactions to the role of stem cells in neurovascular repair. The second section covers experimental methods in rodent and in large animal models of CNS injury, as well as the use of biomaterials and biomarkers in studying the mechanisms of tissue response. The third section deals with clinical issues in the monitoring and treatment of the patient with traumatic injury of the brain and spinal cord. Contributors to the book include an integrated mix of basic scientists and clinicians from diverse institutions. By presenting salient issues in CNS trauma from a vascular perspective, this book should make a unique contribution to the understanding of traumatic brain and spinal cord injury.
Contents:
CNS Barriers in Neurotrauma
Mechanisms of Cerebral Edema Leading to Early Seizures after Traumatic Brain Injury
Human Cerebral Blood Flow and Traumatic Brain Injury
Gliovascular Targets in Traumatic CNS Injury
Neurovascular Responses to Traumatic Brain Injury
The Effects of Intravascular Coagulation and Microthrombosis on Cerebral Perfusion after Brain Trauma
Barriers to Drug Delivery for Brain Trauma
Angiogenesis and Functional Recovery after Traumatic Brain Injury
Vascular Mechanisms in Spinal Cord Injury
Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury
Stem Cells for Neurovascular Repair in CNS Trauma
Vascular Actions of Hypothermia in Brain Trauma
Vascular Responses in Rodent Models of Traumatic Brain Injury
SAH Models: Review, New Modification, and Prospective
Age and Sex Differences In Hemodynamics In a Large Animal Model of Brain Trauma
Neutrophils as Determinants of Vascular Stability in the Injured Spinal Cord
Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke
Biomaterials for CNS Injury
Isolated Blood Vessel Models for Studying Trauma
Managing Edema and Intracranial Pressure in the Intensive Care Unit
Surgical Management of Traumatic Brain Edema
Optimizing Hemodynamics in the Clinical Setting
Cerebrovascular Autoregulation and Monitoring of Cerebrovascular Reactivity
Cerebrovascular Responses after Pediatric Traumatic Brain Injury
Subdural Hematoma in Non-Accidental Head Injury
Blood Genomics after Brain Ischemia, Hemorrhage, and Trauma
Molecular Biomarkers in Neurocritical Care ? The Next Frontier
Bedside Monitoring of Vascular Mechanisms in CNS Trauma: The use of Near Infra-red Spectroscopy (NIRS) and Transcranial Doppler (TCD)
In vivo MRI and MRS of Cerebrovascular Function following Traumatic Brain Injury.