Bookedited by Alexander Vinks, Hartmut Derendorf, Johan Mouton.
Summary: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.
Contents:
Foreword
Section I: Basic Concepts and Principles
Introduction to Pharmacodynamics and micrbiology
In vitro and animal PK/PD model
MIC and breakpoints
Principles of applied PK/PD modeling
Population Pk/PD modeling and its applications to antimicrobials
Drug resistance and Drug-drug combinations
Section II: Clinical
Aminoglycosides
Beta-lactam antibiotics including continuous infusion
Macrolides
Glycopeptides
Quinolones
Other.