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  • Book
    Philip Rubin, Louis S. Constine, Lawrence B. Marks, editors.
    Summary: The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life.

    Contents:
    Prologue : Surviving cancer : SEER statistics
    Biobontinuum of the pathophysiology paradigm
    Biophysiopathology of the microvascular and microcirculation
    Molecular mechanisms of radiation induced therapy
    Biodetection and biointervention : cytokine pathways as a rationale for anti-cytokine interventions post-radiation
    Quantitative/objective analyses of RT-induced late normal tissue injury using functional imaging
    Biograding of normal tissue TNM toxicity taxonomy : scoring the adverse effects of of cancer treatment
    Understanding and predicting radiation-associated normal tissue injury : a global and history perspective
    Biotoxity of chemotherapy
    BioSurveillance and longitudinal lifelong guidelines
    BioPediatric complexities of growth and development
    BioGenetic and host implications
    Bioengineering of irradiated normal tissues by bone marrow stem cells
    Radiotherapy-induced carcinogenesis and Leukemogenesis : mechanisms and quantitative moeling
    The bioepidemiology of MultiplePrimary cancers
    Radiation-related second primary cancers : clinical perspectives
    The psychosocial and functional impact of radiation therapy
    Nursing
    Economic consequences of late effects
    Radiological and nuclear terrorism : relevance to the radiation oncology and biology communities.
    Digital Access Springer 2014