BookElisabetta Baldi, Monica Muratori, editors.
Summary: There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to aging, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. This book provides a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
Contents:
Structure of chromatin in spermatozoa
Genomic changes in spermatozoa of aging male
Chromosomal aberrations and aneuploidies of spermatozoa
The sperm epigenome: implications for the embryo
Environmental epigenetics and effects on male fertility
Protamine alterations in human spermatozoa
Sperm DNA fragmentation and base oxidation
Iatrogenic enetic damage of spermatozoa
Sperm cryopreservation: effect on chromatin structure
Sperm selection: effect on sperm DNA quality
Effect of antioxidant on sperm genetic damage.
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