Bookedited by Mohamed Al-Rubeai.
Summary: Engineered antibodies currently represent over 30 per cent of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in.
Contents:
Expression of antibody in mammalian cells
Bioreactor systems for producing antibody from mammalian cells
Production of antibody in insect cells
Production of monoclonal antibodies in glycoengineered Pichia pastoris
Production of antibodies in Hansenula polymorpha
Production of antibody by transgenic avians
Production of antibodies in plants
Production of antibody fab fragments in Escherichia coli
Intrabody expression in mammalian cells
Engineering antibodies for cancer therapy
Recombinant bispecific antibodies for cancer therapy
The Role of glycosylation in therapeutic antibodies
Quality issues arising from post-translational modification of recombinant antibodies
Recovery and purification of antibody.