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- BookFederico Goodsaid, William B. Mattes.Summary: The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities.Digital Access ScienceDirect 2013
- ArticlePlachot M, Mandelbaum J, de Grouchy J.Ann Genet. 1977 Sep;20(3):167-70.Multi-oocytic follicles containing 2 to 6 oocytes were observed in two female hamsters, a mother and daughter pair. Cultivation rarely permitted more than one oocyte to reach maturation. These findings, which could explain the hereditary character of dizygotic twinning, are compared with observations made in other mammalian species.