Bookedited by Neil Kaplowitz and Laurie Deleve.
Contents:
I. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz
Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich
Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet
Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke
Hepatotoxicity due to mitochondrial injury / John J. Lemasters
Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz
Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick
Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve
Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.]
Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey
Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht
Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale
Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day
II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey
Histopathological evaluationof drug-induced liver disease / David E. Kleiner
Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani
Biomarkers for drug-induced liver injury / Paul B. Watkins
Causality assessment / M. Isabel Lucena ... [et al.]
III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson
Acetaminophen / Laura P. James
Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli
Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine
Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna
Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder
Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault
Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley
Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz
Hepatotoxicity of antiviral agents / Marina Núñez
Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro
Cancer chemotherpay / Laurie D. Deleve
Hepatotoxicity of immunosuppressive drugs / Adrian Reuben
Hepatotoxicity related to methotrexate / Guruprasad P. Aithal
Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell
Mushroom poisoning / François Durand and Dominique Valla
Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro
Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz
Chronic liver disease from drugs / Einar S. Björnsson
IV. Future directions. Regulatory perspectives / Mark I. Avigan
Drug-induced liver injury research networks / Robert J. Fontana
LiverTox / Jay H. Hoofnagle.