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  • Book
    Magdi Hanna, Ben Zylicz, editors.
    Summary: Cancer remains a major challenge for medicine and it continues to claim lives and cause great suffering. Pain is a symptom experienced by most cancer patients regardless of disease stage, and less than 50% of cancer pain patients achieve effective pain and symptom control though available therapies. If these therapies are utilized correctly, many more patients can achieve effective control. While opioids are still seen as the mainstay of cancer pain treatment, it is necessary to examine whether this treatment strategy still holds true in the 21st century. Cancer Pain provides a comprehensive, up-to-date, practical guide to the management of pain in cancer patients. The book provides a clear, concise explanation of cancer pain syndromes, a modern understanding of the pathophysiological mechanism and an overview of recent developments in creating pre-clinical cancer pain models. It offers the reader the wide and improved options for management of cancer pain in clinical practice, including the use of opioid and non-opioid drugs, and defines the role of non-pharmacological methods for pain control. Cancer Pain also provides an overview of the latest developments in the management of cancer, which have major implications for the current and future thinking in cancer pain treatment strategy. This text is an invaluable resource for doctors, trainees and clinical nurse specialists in palliative medicine and oncology, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of cancer pain and the tools available to alleviate it.

    Contents:
    Introduction / Magdi Hanna, Zbigniew (Ben) Zylicz,
    Epidemiology of Pain in Cancer / Irene J. Higginson
    Recent Advances in Cancer Treatment / M. J. Lind
    Pharmacogenetics of Pain in Cancer / Pål Klepstad,
    Mechanisms in Cancer Pain / Jerzy Wordliczek,, Renata Zajaczkowska,
    Preclinical Cancer Pain Models / Joanna Mika, Wioletta Makuch, Barbara Przewlocka
    Pain Assessment, Recognising Clinical Patterns, and Cancer Pain Syndromes / Malgorzata Krajnik,, Zbigniew (Ben) Zylicz,
    Opioids, Their Receptors, and Pharmacology / R. A. F. J. D'Costa, Magdi Hanna
    Critical Appraisal of the Breakthrough Pain in Cancer / Zbigniew (Ben) Zylicz,
    Opioid-Induced Hyperalgesia / Jakob Sørensen, Per SjøgrenSci
    The Non-Pharmacological and Local Pharmacological Methods of Pain Control / Remigiusz Lecybyl,
    New Drugs in Management of Pain in Cancer / Marie Fallon
    Neuropathic Component of Pain in Cancer / Jung Hun Kang, Eduardo Bruera
    Noncancer-Related Pain in Daily Practice / Zbigniew (Ben) Zylicz,
    Rehabilitation of Cancer Patients, a Forgotten Need? / Roberto Casale,, Danilo Miotti
    Psychosocial Aspects of Cancer Pain / Marijana Braš, Veljko Đorđević,
    Spiritual Care and Pain in Cancer / Carlo Leget
    Interventional Techniques in Cancer Pain: Critical Appraisal / Vittorio Schweiger, Enrico Polati, Antonella Paladini
    Access to Opioid Analgesics: Essential for Quality Cancer Care / Willem Scholten
    Challenges for Pain Management in the Twenty-First Century / Mellar P. Davis.
    Digital Access Springer 2013
  • Article
    Booyse FM, Quarfoot AJ, Bell S, Fass DN, Lewis JC, Mann KG, Bowie EJ.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5702-6.
    Aortic endothelial cells from normal pigs and pigs with von Willebrand disease have been established in long-term cultures. Both cultures appeared similar in terms of general growth characteristics, morphologic features and ultrastructure. Immunofluorescent staining of these cultures with chicken (or rabbit) antiporcine ristocetin-Willebrand factor sera (or IgG) resulted in extensive perinuclear staining of the cells in both cultures. Additionally, staining of semiconfluent cultures of normal cells for ristocetin-Willebrand factor revealed an extensive meshwork of distinct, immunologically identifiable ristocetin-Willebrand factor-containing filaments between cells. Immunoreactive material was considerably decreased and more diffuse between cells in semiconfluent cultures from affected pigs. Through immunocytochemical staining with peroxidase-coupled antiserum, the filaments (of indeterminate length) were found to have a diameter of approximately 300 A. Finally, washed porcine platelets interacted extensively with scrape-damaged cultures of affected endothelial cells. This interaction of platelets with damaged normal cultures was abolished by pretreatment of the cultures with rabbit antiporcine ristocetin-Willebrand factor IgG.
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