BookAlexander von Gabain, Christoph Klade, editors.
Summary: Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
Contents:
Skills, Knowledge, and Translational Technologies Leading to Novel Vaccines / Şefik Ş. Alkan
Finding Protective Bacterial Antigens / Guido Grandi and Eszter Nagy
Enhancing and Tailoring the Immunogenicity of Vaccines with Novel Adjuvants / Christopher B. Fox, Benjamin Wizel, Steven G. Reed and Derek T. O'Hagan
Vaccine Delivery: Beyond Needles / David C. Flyer and Barbara Butler
Employing Live Microbes for Vaccine Delivery / Holger Loessner, Astrid Schwantes, Matthias Hamdorf, Uliana Komor and Sara Leschner, et al.
Synthesizing Vaccines with Microbes / Michael Wacker and Danilo R. Casimiro
Purification and Formulation: Silent but Important Players in Vaccine Development / Robert Schlegl and Rainer Hahn
Cutting-Edge Approaches Toward Novel and Cross-Protective Influenza Vaccines / Ruth Arnon and Tamar Ben-Yedidia
Cutting Edge Approaches Toward Novel and Cross-Protective Influenza Vaccines / Kenny Roose, Michael Schotsaert, Karim El Bakkouri, Bert Schepens and Walter Fiers, et al.
Examples of Novel Registered Prophylactic Vaccines, HPV, and JEV / Katrin Dubischar-Kastner, Michelle Vichnin and Carlos Sattler
The Bumpy Road Toward Vaccine Registration: How to Overcome Regulatory Hurdles / Michael Pfleiderer.