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    Md. Shahidul Islam, [editor].
    Summary: "This volume ... [explores] topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative." --Excerpt from publisher's description.

    Contents:
    The Regulation of a Cell's Ca2+ Signaling Toolkit: The Ca2+ Homeostasome / Beat Schwaller
    Methods to Detect Ca2+ in Living Cells / Joseph D. Bruton, Arthur J. Cheng and Håkan Westerblad
    Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs / Irina Vetter
    Two-Photon Calcium Imaging in the Intact Brain / Marco Dal Maschio, Riccardo Beltramo, Angela Michela De Stasi and Tommaso Fellin
    Signaling Through the Extracellular Calcium-Sensing Receptor (CaSR) / Bandana Chakravarti, Naibedya Chattopadhyay and Edward M. Brown
    Ca2+ Signaling: An Outlook on the Characterization of Ca2+ Channels and Their Importance in Cellular Functions / Jordan Karlstad, Yuyang Sun and Brij B. Singh
    Ryanodine Receptor Calcium Release Channels: An Evolutionary Perspective / John J. Mackrill
    Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level / Cedric Viero, N. Lowri Thomas, Joanne Euden, Sammy A. Mason and Christopher H. George, et al.
    Ryanodine Receptor Physiology and Its Role in Disease / Johanna T. Lanner
    Phospholipase C / Charlotte M. Vines
    Inositol 1,4,5-Trisphosphate and Its Receptors / Jan B. Parys and Humbert De Smedt
    The Discovery and Structural Investigation of the IP3 Receptor and the Associated IRBIT Protein / Katsuhiko Mikoshiba. Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores / Antony Galione and Kai-Ting Chuang
    NAADP on Target / Robert Hooper and Sandip Patel
    Store-Operated Ca2+ Entry / Alejandro Berna-Erro, Pedro C. Redondo and Juan A. Rosado
    Structure, Regulation and Biophysics of ICRAC, STIM/Orai1 / Isabella Derler, Josef Madl, Gerhard Schütz and Christoph Romanin
    Mitochondria-Associated Membranes (MAMs) as Hotspot Ca2+ Signaling Units / Angela Bononi, Sonia Missiroli, Federica Poletti, Jan M. Suski and Chiara Agnoletto, et al.
    Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking / Massimo Micaroni
    Calcium Binding Proteins / Matilde Yáñez, José Gil-Longo and Manuel Campos-Toimil
    Cytoplasmic Calcium Buffering / Juan A. Gilabert
    Elementary Calcium Release Events from the Sarcoplasmic Reticulum in the Heart / Didier X. P. Brochet, Dongmei Yang, Heping Cheng and W. Jonathan Lederer
    Calcium Oscillations and Pacemaking / Mohammad S. Imtiaz
    Calcium Oscillations and Waves in Cells / Jai Parkash and Kamlesh Asotra
    Calcium Signaling: From Single Channels to Pathways / Alexander Skupin and Kevin Thurley
    Simulation Strategies for Calcium Microdomains and Calcium-Regulated Calcium Channels / Frederic von Wegner, Nicolas Wieder and Rainer H. A. Fink
    Combined Computational and Experimental Approaches to Understanding the Ca2+ Regulatory Network in Neurons / Elena É. Saftenku and David D. Friel. [alpha]7 Nicotinic ACh Receptors as a Ligand-Gated Source of Ca2+ Ions: The Search for a Ca2+ Optimum / Victor V. Uteshev
    The Biology of Protein Kinase C / Lily Zeng, Samuel V. Webster and Philip M. Newton
    The Role of C2 Domains in PKC Signaling / Carole A. Farah and Wayne S. Sossin
    Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart / Lars S. Maier
    The Role of Molecular Regulation and Targeting in Regulating Calcium/Calmodulin Stimulated Protein Kinases / Kathryn A. Skelding and John A. P. Rostas
    Calcium Sensing in Exocytosis / Natalia Gustavsson, Bingbing Wu and Weiping Han
    Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins / Norbert Weiss and Gerald W. Zamponi
    Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels / Juan A. Orellana, Helmuth A. Sánchez, Kurt A. Schalper, Vania Figueroa and Juan C. Sáez
    Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology / Alexandre Marchand, Aniella Abi-Gerges, Youakim Saliba, Elise Merlet and Anne-Marie Lompré
    Calcium and Endothelium-Mediated Vasodilator Signaling / Shaun L. Sandow, Sevvandi Senadheera, T. Hilton Grayson, Don G. Welsh and Timothy V. Murphy
    Calcium Signaling in Cerebral Vasoregulation / Shantanu Ghosh and Amrita Basu
    Ca2+ Signaling Mechanisms in Bovine Adrenal Chromaffin Cells / Jamie L. Weiss
    Calcium Stores in Vertebrate Photoreceptors / David Križaj. Stem Cells and Calcium Signaling / Fernanda M. P. Tonelli, Anderson K. Santos, Dawidson A. Gomes, Saulo L. da Silva and Katia N. Gomes, et al.
    Calcium Signaling in Osteoclast Differentiation and Bone Resorption / Hiroshi Kajiya
    Calcium Signaling in Renal Tubular Cells / Milica Bozic and Jose M. Valdivielso
    Calcium in Epidermis / Martin J. Behne and Jens-Michael Jensen
    Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels / Yoshihiro Suzuki, Toshio Inoue and Chisei Ra
    Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer / Roland Kaufmann and Morley D. Hollenberg
    Mechanosensory Calcium Signaling / Thomas J. Jones and Surya M. Nauli
    Role Ca2+ in Mechanisms of the Red Blood Cells Microrheological Changes / Alexei Muravyov and Irina Tikhomirova
    Calcium Imaging in the Zebrafish / Petronella Kettunen
    Calcium Signaling in Xenopus oocyte / Matthieu Marin
    Calcium Oscillations, Oocyte Activation, and Phospholipase C zeta / Junaid Kashir, Celine Jones and Kevin Coward
    Nuclear Calcium Signaling and Its Involvement in Transcriptional Regulation in Plants / Benoit Ranty, Valérie Cotelle, Jean-Philippe Galaud and Christian Mazars
    Remodeling of Calcium Handling in Human Heart Failure / Qing Lou, Ajit Janardhan and Igor R. Efimov
    Proarrhythmic Atrial Calcium Cycling in the Diseased Heart / Niels Voigt, Stanley Nattel and Dobromir Dobrev
    Neuronal Calcium Signaling and Alzheimer's Disease / Neha Kabra Woods and Jaya Padmanabhan
    Voltage-Gated Ca2+ Channel Mediated Ca2+ Influx in Epileptogenesis / Magdalena Siwek, Christina Henseler, Karl Broich, Anna Papazoglou and Marco Weiergräber.
    Digital Access Springer 2012