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  • Book
    Cornelis Murre, editor.
    Summary: Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.

    Contents:
    Roles of lineage-determining transcription factors in establishing open chromatin : lessons from high-throughput studies / Sven Heinz and Christopher K. Glass
    B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1 / James Hagman, Julita Ramírez and Kara Lukin
    Epigenetic features that regulate IgH locus recombination and expression / Ramesh Subrahmanyam and Ranjan Sen
    Local and global epigenetic regulation of V(D)J recombination / Louise S. Matheson and Anne E. Corcoran
    Genetic and epigenetic regulation of Tcrb gene assembly / Michael L. Sikes and Eugene M. Oltz
    T-cell identity and epigenetic memory / Ellen V. Rothenberg and Jingli A. Zhang
    Encoding stability versus flexibility : lessons learned from examining epigenetics in T helper cell differentiation / Kenneth J. Oestreich and Amy S. Weinmann
    The epigenetic landscape of lineage choice : lessons from the heritability of Cd4 and Cd8 expression / Manolis Gialitakis, MacLean Sellars and Dan R. Littman.
    Digital Access Springer 2012
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    2011