BookMaria M. Picken, Ahmet Dogan, Guillermo A. Herrera, editors.
Summary: Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Contents:
Part 1.; Introduction/General
1. Aspects of the History and Nomenclature of Amyloid and Amyloidosis / Per Westermark
2. Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis / Mario Nuvolone, Giovanni Palladini and Giampaolo Merlini
3. AA Amyloidosis / Amanda K. Ombrello and Ivona Aksentijevich
4. The Hereditary Amyloidoses / Merrill D. Benson
5. Dialysis-Associated Amyloidosis / Paweena Susantitaphong, Laura M. Dember and Bertrand L. Jaber
6. Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System / Per Westermark
7. Cerebrovascular Amyloidoses / John M. Lee and Maria M. Picken
Part 2. Non-Amyloid Protein Deposits
8. Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis / Guillermo A. Herrera and Elba A. Turbat-Herrera
9. Light/Heavy Chain Deposition Disease as a Systemic Disorder / Guillermo A. Herrera and Elba A. Turbat-Herrera
10. Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits / Pierre Ronco, Alexandre Karras and Emmanuelle Plaisier
11. Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond / Maria M. Picken
Part 3. Diagnosis
12. Diagnosis of Amyloid Using Congo Red / Alexander J. Howie
13. Diagnosis of Minimal Amyloid Deposits Using the Congo Red Fluorescence Method: A Review / Reinhold P. Linke
14. Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection / Maria M. Picken and Guillermo A. Herrera
15. Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis / Johan Bijzet, Ingrid I. van Gameren and Bouke P. C. Hazenberg --16. Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editorial Comments on Chaps. 12-15 / Maria M. Picken
17. Routine Use of Amyloid Typing on Formalin-Fixed Paraffin Sections from 626 Patients by Immunohistochemistry / Reinhold P. Linke
18. Amyloid Typing: Experience from a Large Referral Centre / Janet A. Gilbertson, Toby Hunt and Philip N. Hawkins
19. Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chaps. 17-19) / Maria M. Picken --20. Amyloid Typing: Immunoelectron Microscopy / Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici and Vittorio Necchi, et al.
21. Classification of Amyloidosis by Mass Spectrometry-Based Proteomics / Ahmet Dogan
Part 4. Ancillary Studies of Amyloidosis
22. Laboratory Support for Diagnosis of Amyloidosis / David L. Murray and Jerry A. Katzmann
23. Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias / Sujata Ramamurthy, Lawreen H. Connors and Carl J. O'Hara --24. Laboratory Methods for the Diagnosis of Hereditary Amyloidoses / S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond and W. Edward Highsmith
Part 5. Organ Involvement in Amyloidoses
25. Amyloidoses of the Kidney and Genitourinary Tract / Maria M. Picken
26. Cardiac Amyloidosis / Carmela D. Tan and E Rene Rodriguez --27. Amyloidosis of the Gastrointestinal Tract and Liver / Oscar W. Cummings and Merrill D. Benson
28. Peripheral Nerve Amyloidosis / Adam J. Loavenbruck, Janean K. Engelstad and Christopher J. Klein --29. Clinical and Pathologic Issues in Patients with Amyloidosis: Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation / Jay S. Dalal, Kevin Barton and Maria M. Picken --30. Emerging Therapies for Amyloidosis / Merrill D. Benson
31. Modern Therapies in AA Amyloidosis / Amanda K. Ombrello
32. Medicolegal Issues of Amyloidosis / Timothy Craig Allen
33. Amyloidosis from the Patient's Perspective / Muriel Finkel.