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  • Book
    editor, Roger N. Rosenberg ; with 55 contributors.
    Contents:
    Developmental disorders / Suresh Kotagal ... [et al.]
    Genetic diseases of the nervous system / Thomas D. Bird and Suman Jayadev
    Neuroendocrine disorders / Earl A. Zimmerman
    Critical care neurology / Marek A. Mirski ... [et al.]
    Cerebrovascular disease / David M. Greer ... [et al.]
    Dementias / Thomas J. Grabowski Jr.
    Behavioral neurology / Daniel Tranel and Thomas J. Grabowski, Jr.
    Neuro-oncology / Karen L. Fink and Elisabeth J. Rushing
    Movement disorders / Stanley Fahn ... [et al.]
    The epilepsies / Paul C. Van Ness
    Neuromuscular disease / Gil I. Wolfe ... [et al.]
    Infectious diseases of the nervous system / Burk Jubelt
    Neuroimmunology / Michael R. Swenson
    Neurotoxic disorders / Leon Prockop, Charles Brock, and Peter S. Spencer
    Headache / Marc E. Lenaerts.
    Digital Access Springer 2009
  • Article
    Goto M, Yatani A, Tsuda Y.
    Jpn J Physiol. 1977;27(1):81-94.
    The effect of adenosine compounds (ATP, ADP, AMP and adenosine) on membrane potential, current and contractile tension on the bullfrog atrium were studied under voltage clamped and unclamped conditions. The compounds produced immediate positive and late negative inotropic effects in unclamped conditions. The positive inotropic effect and the potency of drugs appeared less marked in the order of ATP, ADP, AMP, and adenosine. Under voltage clamped conditions, only the energy rich compounds, ATP and ADP, produced an enhancement of calcium inward current (Ica) and Ica-dependent phasic tension, while AMP and adenosine elicited a negative inotropic effect. The delayed outward current was initially depressed but later augmented epecially in case of ATP and ADP where Ica was enhanced. All adenosine compounds, however, inhibited the Ica-independent tonic tension. This effect, appearing nonspecific, was ascribable to the action of common structure of these compounds, purine-riboside moiety.
    Digital Access Access Options