BookJeffrey E. Green, Thomas Ried, editors.
Contents:
Overview of designing genetically engineered mouse (GEM) models
Use of Cre-loxP technology and inducible systems to generate mouse models of cancer
Using recombineering technology to create genetically engineered mouse models
Insertional mutagenesis for generating mouse models of cancer
RCAS/TVA somatic gene transfer method in modeling human cancer
Target-selected ENU mutagenesis to develop cancer models in the rat
Tumor pathology of genetically engineered mice: genomic pathology
Genomic DNA copy number alterations in mouse cancer models and human cancer
Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry
Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing
Imaging mouse models of human cancer
Identifying mammary epithelial stem and progenitor cells
Differentiation programs in development and cancer
Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse
Mouse models for colorectal cancer
Src family tyrosine kinases: implications for mammary tumor progression
Maspin and suppresion of tumor metastasis
Epigenetic mouse models
Modeling transforming growth factor-ss signalling in cancer
Modeling stromal-epithelial interactions
Utilizing mouse models of human cancer for assessing immune modulation of cancer development
Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models
Development and use of genetically tractable preclinical mouse models
Animal models for breast cancer prevention research
Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies
Mouse models in preclinical drug development: applications to CNS models
Mouse models of human cancer: role in preclinical testing and personalized medicine
Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.