Bookedited by Mark R. Kelley.
Contents:
Introduction and overview of current targets: bench to clinic / Mark R. Kelley
2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu
3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto
4. PARP inhibitors
scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew
5. Inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis
6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick
7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle
8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller
9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li
10. DNA repair signaling targets / Susan Ashwell
11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis
12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan
13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko
14. Future directions with DNA repair inhibitors / Mark R. Kelley.