The Difficulty of Assessing Quality or Quality-of-Life -- The Role of Language in Assessing Quality or Quality-of-Life -- What Role Do Cognitive Processes Play in Assessing Quality or Quality-of-Life? -- The Role of Objective or Subjective Indicators -- The Role of Signs or Symptoms -- Summary Measurement: The Role of Categories or Domains -- Symptoms and HRQOL Assessment -- Health Status and HRQOL Assessment -- Functional Status and HRQOL -- Neurocognition and HRQOL Assessment -- Well-Being as an Indicator of Quality or Quality-of-Life -- Summary and Future Directions.