Part 1. Pre-clinical development -- The Discovery and Characterisation of Tumour Endothelial Markers / Dario Neri and Roy Bicknell -- The Use of Animal Models in the Assessment of Tumour Vascular Disrupting Agents (VDAs) / R. Barbara Pedley and Gillian M. Tozer -- Combination Therapy with Chemotherapy and VDAs / Giulia Taraboletti, Katiuscia Bonezzi and Raffaella Giavazzi -- Lessons from Animal Imaging in Preclinical Models / Lesley D. McPhail and Simon P. Robinson -- Combining Antiangiogenic Drugs with Vascular Disrupting Agents Rationale and Mechanisms of Action / Yuval Shaked, Paul Nathan, Laura G. M. Daenen and Robert S. Kerbel -- Development of Vascular Disrupting Agents / Graeme J. Dougherty and David J. Chaplin -- Part 2. Imaging in the development of vascular disruptive agents -- MRI to Assess Vascular Disruptive Agents / Martin Zweifel and Anwar R. Padhani -- Contrast Ultrasound in Imaging Tumor Angiogenesis / Grzegorz Korpanty and Rolf A. Brekken -- Part 3. Clinical development -- The Clinical Development of Tubulin Binding Vascular Disrupting Agents / Martin Zweifel and Gordon Rustin -- ASA404 (DMXAA): New Concepts in Tumour Vascular Targeting Therapy / Bruce C. Baguley -- Vascular Disruptive Agents in Combination with Radiotherapy / Henry C. Mandeville and Peter J. Hoskin.