BookLaurence A. Cole, Stephen A. Butler.
Contents:
Part A: Introduction
1. The Expanding World of hCG
2. History and Introduction to Human Chorionic Gonadotropin (hCG): One Name for at Least Three Independent Molecules
3. Introduction to Pregnancy Implantation, Villous Formation, and Hemochorial Placentation
Part B: Genetics, Synthesis, Secretion, Structure, and Degradation of hCG
4. The Molecular Genetics of hCG
5. Structure, Synthesis, Secretion, and Function of hCG
6. Comparison of the Structures of hCG and Hyperglycosylated hCG
7. Structures of Free a- and ss-Subunits
8. Glycobiology of hCG
9. Degradation Products of hCG, Hyperglycosylated hCG, and Free ss-Subunit
10. Three-Dimensional Structure of hCG
Part C: Biological Function of hCG
11. Paradigm Shift on the Targets of hCG Actions
12. The hCG Receptor
13. Biological Function of Hyperglycosylated hCG
14. Biological Function of the Free ss-Subunit: Expression and Treatment Target in Cancer
Part D: Clinical Applications
15. Use of hCG in Reproductive Dysfunction
16. hCG in Assisted Reproduction
17. Illicit Use of hCG in Dietary Programs and Use to Promote Anabolism
Part E: hCG Tests
18. Antibodies for Intact hCG, for Total hCG, for Free Subunits, Glycosylation Variants, and for hCG Fragments
19. Quantitative hCG Assays
20. False Positive hCG Assays
21. Specificity of Different hCG Assays
22. Point-of-Care Pregnancy Tests
23. Over-the-Counter Pregnancy Tests
24. hCG Standards
Part F: Test Applications
25. Background hCG
26. Pregnancy Testing
27. Predicting Spontaneously Aborted (SAB) Pregnancies
28. hCG, Hyperglycosylated hCG, and Free ss-Subunit in Predicting Down Syndrome Pregnancies and Preeclampsia
29. hCG in Monitoring Gestational Trophoblastic Diseases
30. Use of Hyperglycosylated hCG as a Unique Marker of Gestational Trophoblastic Neoplasms
31. Pituitary hCG and Familial hCG
32. hCG, Free ss-Subunit, and ss-Core Fragment as Markers of Malignancies
Part G: Basic Methods
33. hCG and Hyperglycosylated hCG Purification and Analysis from Serum, Urine, and Culture Fluids
34. Dissociation, Desialylation, and Cleavage of hCG
35. hCG and Free ss-Subunit Producing Cell Lines
Part H: Evolution, Summary, and the Future
36. Evolution of hCG, Evolution of Humans, and Evolution of Human Pregnancy Disorders and Cancer
37. Summary: hCG a Remarkable Molecule
38. hCG and the Future.