BookAbraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin, editors.
Summary: The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer's disease and Parkinson's disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume.
Contents:
1. Clinical Features and Treatment of Dementia Associated With Parkinson's Disease / Murat Emre
2. Neurogenetics in Parkinson's Disease / Yoshikuni Mizuno and Nobutaka Hattori
3. Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity / Simona Francisconi, Mara Codenotti, Erminia Poli, Daniela Uberti, Giulia Ferrari-Toninelli, and Maurizio Memo
4. Current Problems and Strategies in Motor Rehabilitation for Parkinson's Disease / Giovanni Abbruzzese, Elisa Pelosin, and Roberta Marchese
5. Critical Acute Akinesia in Parkinson's Disease Patients Concomitant with Additional Precipitating Factors Other Than Treatment Withdrawal: A Possible Lethal Complication / Marco Onofrj and Astrid Thomas
6. Biomarkers for Early Detection of Parkinson's Disease: An Essential Challenge / Florian Tribl and Peter Riederer
7. Neurotransmitter and Neurotrophic Factor-Secreting Cell Line Grafting for the Treatment of Parkinson's Disease / Isao Date, Tetsuro Shingo, and Takao Yasuhara
8. Novel Therapeutic Target in PD: Experimental Models / Francesco Fornai
9. LRRK2 (Leucine-Rich Repeat Kinase 2) Gene on PARK8 Locus in Families with Parkinsonism / Zbigniew K. Wszolek, Alexander Zimprich, Saskia Biskup, Ryan J. Uitti, Donald B. Calne, A. Jon Stoessl, Akiko Imamura, Matthew J. Farrer, Judith Miklossy, Thomas Meitinger, Thomas Gasser, Dennis W. Dickson, and Patrick L. McGeer
10. Microglia Activation and Gene Expression of Cytokines in Parkinson's Disease / Makoto Sawada, Kazuhiro Imamura, and Toshiharu Nagatsu
11. Dissecting the Biochemical Pathways Mediated by Genes Implicated in Parkinson's Disease: Induction of DJ-1 Expression in A30P [alpha]-Synuclein Mice / Mark Frasier, Shanti Frausto, Daniel Lewicki, Lawrence Golbe, and Benjamin Wolozin
12. Neuroinflammation in Early Stages of Alzheimer's Disease and Parkinson's Disease / Piet Eikelenboom, A. Crosswell, C. van Engen, M. Limper, J.J.M. Hoozemans, R. Veerhuis, W.A. van Gool, and J.M. Rozemuller
13. Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Dementias: Different Manifestations of Protein Misfolding / John Q. Trojanowski, Mark S. Forman, and Virginia M-Y. Lee
14. Role of Oxidative Insult and Neuronal Survival in Alzheimer's and Parkinson's Diseases / Akihiko Nunomura, Paula I. Moreira, Xiongwei Zhu, Adam D. Cash, Mark A. Smith, and George Perry
15. Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain and in Brain from a Rodent Model of Familial Parkinson's Disease: Insights into Potential Mechanisms of Neurodegeneration / Rukhsana Sultana, H. Fai Poon, and D. Allan Butterfield
16. Biomarkers for Alzheimer's Disease and Parkinson's Disease / John H. Growdon, Michael C. Irizarry, and Clemens Scherzer
17. Bioluminescent Imaging of Excitotoxic and Endotoxic Brain Injury in Living Mice / Jian Luo, Amy H. Lin, and Tony Wyss-Coray
18. Alzheimer's Disease Neuroimaging Initiative / Susanne G. Mueller, Michael W. Weiner, Leon J. Thal, Ronald C. Petersen, Clifford Jack, William Jagust, John Q. Trojanowski, Arthur W. Toga, and Laurel Beckett
19. Two Hits and You're Out? A Novel Mechanistic Hypothesis of Alzheimer Disease / Xiongwei Zhu, George Perry, and Mark A. Smith
20. Vascular Risk Factors and Risk for Alzheimer's Disease and Mild Cognitive Impairment: Population Based Studies / Hilkka Soininen, Miia Kivipelto, and Aulikki Nissinen
21. Cholesterol Transport and Production in Alzheimer's Disease / Judes Poirier, Louise Lamarre-Théroux, Doris Dea, Nicole Aumont, and Jean Francois Blain
22. Cholesterol and A[beta] Production: Methods for Analysis of Altered Cholesterol De Novo Synthesis / Jakob A. Tschäpe, Marcus O.W. Grimm, Heike S. Grimm, and Tobias Hartmann
23. Glycosaminoglycans and Analogs in Neurodegenerative Disorders / Lucilla Parnetti and Umberto Cornelli
24. Prospective Role of Glycosaminoglycans in Apoptosis Associated with Neurodegenerative Disorders / Bertalan Dudas, Amira Lemes, Umberto Cornelli, and Israel Hanin
25. Stem Cell Therapy in Alzheimer's Disease / Kiminobu Sugaya, Young-Don Kwak, and Angel Alvarez
26. Oral A[beta] Vaccine Using a Recombinant Adeno-Associated Virus Vector in an Alzheimer's Disease Mouse Model / Takeshi Tabira and Hideo Hara
27. In Vivo Targeting of Amyloid Plaques Via Intranasal Administration of Phage Anti-[beta]-Amyloid Antibodies / Beka Solomon
28. Decreased ProBDNF: The Cause of Alzheimer's-Associated Neurodegeneration and Cognitive Decline? / Margaret Fahnestock, S. Peng, D.J. Garzon, and Elliott J. Mufson
29. Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer's Disease / Elliott J. Mufson, Scott E. Counts, S. Peng, and Margaret Fahnestock
30. Neuroprotective Effects of Trophic Factors and Natural Products: Involvement of Multiple Extracellular Kinases / Stéphane Bastianetto, Wen-Hua Zheng, Yingshan Han, Lixia Gan, and Rémi Quirion
31. Intraneuronal A[beta] and Alzheimer's Disease / Lauren M. Billings and Frank M. LaFerla
32. Physiological Processing of the Cellular Prion Protein and [Beta]APP: Enzymes and Regulation / Bruno Vincent, Moustapha Alfa Cisse, and Frédéric Checler
33. Expression of Wnt Receptors, Frizzled, in Rat Neuronal Cells / Marcelo A. Chacón, Marcela Columbres, and Nibaldo C. Inestrosa
34. Cell Models of Tauopathy / J. Biernat, I. Khlistunova, Y-P. Wang, M. Pickhardt, M. von Bergen, Z. Gazova, Eckhart Mandelkow, and Eva-Marie Mandelkow
35. Co-expression of FTDP-17 Human Tau and GSK-3[beta](or APP[superscript:]SW) in Transgenic Mice: Induction of Tau Polymerization and Neurodegeneration / Jésus Avila, Tobias Engel, José J. Lucas, Mar Pérez, Alicia Rubio, and Félix Hernández
36. Enhanced Activation of NF-[kappa]B Signaling by Apolipoprotein E4 / Gal Ophir, Liza Mizrahi, and Daniel M. Michaelson
37. Pleiotropic Effects of Apolipoprotein E in Dementia: Influence on Functional Genomics and Pharmacogenetics / Rámon Cacabelos
38. Up-regulation of the [alpha]-Secretase Pathway / Falk Fahrenholz, Claudia Prinzen, Rolf Postina, and Elżbieta Kojro
39. Frequency and Relation of Argyrophilic Grain Disease and Thorn-Shaped Astrocytes in Alzheimer's Disease / Hirotake Uchikado, Yasuhiro Fujino, Wenlang Lin,and Dennis Dickson
40. Cellular Membranes as Targets in Amyloid Oligomer Disease Pathogenesis / Erene W. Mina and Charles G. Glabe
41. Ganglioside-Dependent Generation of a Seed for Alzheimer's Disease Amyloid / Katsuhiko Yanagisawa
42. Evidence That Amyloid Pathology Progresses in a Neurotransmitter-Specific Manner / Karen F.S. Bell and A. Claudio Cuello
43. Rationale for Glutamatergic and Cholinergic Approaches for the Treatment of Alzheimer's Disease / Paul T. Francis and Sara L. Kirvell
44. Cortical Cholinergic Lesion Causes A[beta]Deposition: Cholinergic-Amyloid Fusion Hypothesis / Thomas Beach, Pamela Potter, Lucia Sue, Amanda Newell, Marissa Poston, Raquel Cisneros, Yoga Pandya, Abraham Fisher, Alex Roher, Lih-Fen Lue, and Douglas Walker
45. Expression of Acetylcholinesterase in Alzheimer's Disease Brain: Role in Neuritic Dystrophy and Synaptic Scaling / David H. Small, Steven Petratos, Sharon Unabia, and Danuta Maksel
46. Role of [beta]-Amyloid in the Pathophysiology of Alzheimer's Disease and Cholinesterase Inhibition: Facing the Biological Complexity to Treat the Disease / Stefano Govoni, Michela Mazzucchelli, S. Carolina Lenzken, Emanuela Porrello, Cristina Lanni, and Marco Racchi
47. Dissociation Between the Potent [beta]-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine / Nigel H. Greig, Tada Utsuki, Qian-sheng Yu, Harold W. Holloway, Tracyann Perry, David Tweedie, Tony Giordano, George M. Alley, De-Mao Chen, Mohammad A. Kamal, Jack T. Rogers, Kumar Sambamurti, and Debomoy K. Lahiri
48. Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders / Emanuele Sher, Giovanna De Filippi, T. Baldwinson, Ruud Zwart, Kathy H. Pearson, Martin Lee, Louise Wallace, Gordon I. McPhie, Martine Keenan, Renee Emkey, Sean P. Hollinshead, Colin P. Dell, S. Richard Baker, Michael J. O'Neil, and Lisa M. Broad.